TAS Model
ASTROTAS Model
The Translaminar Autonomous System (TAS) model is one of a kind humanized model to study pressure inside the posterior segment (intraocular) of the eye and the area surrounding the optic nerve (intracranial) to generate a translaminar pressure gradient similar to normal and pathological conditions.
This biologically relevant patented model is utilized to investigate disease mechanisms, identify biomarkers, and evaluate novel interventions for ocular pressure-related neurodegeneration. The TAS system has also been applied by NASA to study consequences of space flight missions on astronaut eyes. The TAS system is designed to fit human donor posterior segment (back of the eye) postmortem tissues and has been validated and featured in numerous peer reviewed publications.
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Human
Organoid and Cell Culture Models
Human analog models are an increasingly popular model to study human cells in a laboratory setting.
Retinal organoids are miniature 3-D tissues grown from human cells. These organoids incorporate multiple retinal cell types to imitate the human retinal tissue.
This 3D culture model is used to study disease pathology, biomarkers, and potential therapeutics.
Retinal ganglion cells (RGCs) from human eyes can be isolated and cultured for disease modeling and therapeutic validation.
Cell culture models are ideal for understanding cellular signals and provide the first line analysis for proof of concept.